Converting woody invasive plant waste to bioenergy is shown to provide affordable energy while controlling invasive alien plants, thus uniting lignocellulosic bioenergy infrastructure with ecological restoration. Evidence of the energy/ecology partnership was demonstrated in a study in eastern Washington, which includes the reservation of the Confederated Tribes and Bands of the Yakama Nation and five surrounding counties. We developed a spatially-explicit cost model illustrating that residues from the eradication of invasive trees can be sold at a competitive price into the regional, woody-biomass market. Selling the invasive plant wood waste has the potential to generate revenues that can support further ecological restoration. However, generating profit from invasive species inherently presents an ecological risk, namely, a supply-side economic incentive to cultivate the invasive plant more extensively. To assess the potential bioenergy demand for these residues, we compare the physicochemical properties of the invasive trees Russian olive (Eleagnus angustifolia) and salt cedar (including Tamarix ramosissima, T. chinensis, and hybrids) to the properties of the average regional biomass feedstock supply. It is shown that Russian olive and salt cedar have properties that are aberrant from the regional biomass supply. These physicochemical divergences from the normal supply stock have technological implications that place natural demand-side constraints on the economic incentives associated with cultivating Russian olive or salt cedar in this region. The integrative analysis performed here can be replicated in other regions, where the predominant biomass supply, energy conversion technologies, and invasive plants may differ substantially from our region.